Program

Timetable

Timetable

Distinguished Lecture 1

November 29 (Wed.) 13:50-14:50 Room A (5F Big Hall)

Variability of drug metabolism due to (epi)genetic and (patho)physiological factors - the struggle for better prediction

  • Chairs: Hiroshi Yamazaki Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
  •  Miki Nakajima Faculty of Pharmaceutical Sciences, Kanazawa University
  • Speaker: Ulrich M. Zanger Molecular and Cell Biology, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Germany

Distinguished Lecture 2

November 30 (Thu.) 13:00-14:00 Room A (5F Big Hall)

Establishing the Selectivity of Organic Cation Transporters: Grappling with Inconvenient Truths

  • Chair: Mikihisa Takano Graduate School of Biomedical & Health Sciences, Hiroshima University
  •  Carsten Ehrhardt School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin
  • Speaker: Stephen H. Wright Department of Physiology, College of Medicine, University of Arizona, Tucson, AZ

President's Lecture

November 30 (Thu.) 15:30-16:00 Room A (5F Big Hall)

Message from the JSSX President: Current topics in drug metabolism and pharmacokinetics and clinical pharmacotherapy

  • Chair: Mikihisa Takano Graduate School of Biomedical & Health Sciences, Hiroshima University
  • Speaker: Hiroshi Yamazaki Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

Symposium 1

November 29 (Wed.) 9:30-11:30 Room A (5F Big Hall)

Recent topics of interface of between "Drug Metabolism and Pharmacokinetics" and "Toxicology"

  • Organizer: Miki Nakajima Faculty of Pharmaceutical Sciences, Kanazawa University
  • Chairs: Kousei Ito Graduate School of Pharmaceutical Sciences, Chiba University
  •  Yoichi Naritomi Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc.
  • "Strategic Drug Design to Eliminate Metabolic Activation of Hapatotoxic Drugs"
  • Speaker: Tomoyuki Ohe Faculty of Pharmacy, Keio University
  • "Application of cytochrome P450 reactivity assessment to liver toxicity prediction"
  • Speaker: Takamitsu Sasaki Depertment of Molecular Toxicology, School of Phrmaceutical Sciences, University of Shizuoka
  • "Bile acid dependent hepatocytes toxicity - beyond BSEP inhibition by parent drug"
  • Speakers: Kousei Ito Graduate School of Pharmaceutical Sciences, Chiba University
  • "Assessment of drug-induced hepatotoxicity, considering drug metabolism, using 3-D hepatocyte cultures and chimeric mice with humanized liver"
  • Speaker: Seigo Sanoh Graduate School of Biomedical and Health Sciences, Hiroshima University

Symposium 2

November 29 (Wed.) 9:30-11:30 Room B (5F Small Hall)

Roles of Pharmacokinetic Studies on Cell Therapeutics

  • Organizer: Takashi Kuwabara Department of Clinical Pharmacy, Yokohama University of Pharmacy
  • Chairs: Makiya Nishikawa Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science
  •  Masataka Oitate Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd.
  • "Biodistribution evaluation in "MEASURE", the Multisite Evaluation Study on Analytical Methods for Non-clinical Safety Assessment of Human-derived Regenerative Medical Products"
  • Speaker: Masahiro Yahata Preclinical Research Laboratories, Sumitomo Dainippon Pharma Co., Ltd.
  • "Biodistribution study of human mesenchymal stem cells in mice using ARLG, IVIS, and qPCR"
  • Speaker: Takahiro Nakamura Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd.
  • "Cell-based therapy with high safety through manipulating the in vivo fate of transplanted cells"
  • Speaker: Kosuke Kusamori Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science
  • "Cell-injection therapy for the treatment of corneal endothelial dysfunction"
  • Speaker: Noriko Koizumi Department of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University

Symposium 3

November 29 (Wed.) 9:30-11:30 Room C (2F Tougen-Fukuju)

From academic research to clinic based on cooperation between industry, government and academia

  • Organizers / Chairs: Hideyoshi Harashima Faculty of Pharmaceutical Sciences Laboratory for Molecular Design of Pharmaceutics, Hokkaido University
  •  Yoshinobu Takakura Graduate School and Faculty of Pharmaceutical Sciences, Kyoto University
  • "Drug discovery Innovation for nonstandard peptides"
  • Speaker: Hiroaki Suga Department of Chemistry, Graduate School of Science, The University of Tokyo
  • "Model-based Population Pharmacokinetic Analysis and Exposure-Response Analysis of Nivolumab"
  • Speaker: Tomoya Ohno ONO Pharmaceutical CO., LTD., Translational Medicine Center, Clinical Pharmacology
  • "Viewpoint on Assessment of Healthcare Technologies"
  • Speaker: Yoshihide Esaki Ministry of Economy, Trade and Industry
  • "Challenge to improve probability of drug discovery and streamline clinical development cost"
  • Speaker: Kazuhiko Mori Ministry of Health, Labour and Welfare

Symposium 4

November 29 (Wed.) 15:00-17:00 Room A (5F Big Hall)

QSP in oncology - practical application, challenge and opportunity -

  • Organizers: Masayo Oishi Clinical pharmacology, Pfizer Japan Inc.
  •  Koji Chiba Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy.
  • Chairs: Hiroto Hatakeyama Laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University
  •  Naomi Nagai Department of Pharmaceutical Sciences, Musashino University
  • "Systems-based understanding of mechanisms underlying the adverse reactions with kinase inhibitors"
  • Speaker: Masashi Honma Department of Pharmacy, the University of Tokyo Hospital
  • Chairs: Yuko Mori Clinical pharmacology, Pfizer Japan Inc.
  •  Yasuhisa Nagasaka Quantitative Systems Pharmacology, Analysis & Pharmacokinetics Research Labs, Astellas Pharma Inc.
  • "QSP Models in Preclinical Oncology Drug Discovery"
  • Speaker: Mary E. Spilker Translational Modeling and Simulation, Medicine Design, Pfizer Worldwide Research and Development
  • Chairs: Teruki Hamada Drug Disposition & Analysis, Research Division, Axcelead Drug Discovery Partners, Inc.
  •  Noriko Okudaira Clinical Pharmacology Department, R&D Division, Daiichi Sankyo Co., Ltd.
  • "An Integrated Mechanistic Model to Characterize Efficacy and Toxicity of Antibody Drug Conjugates"
  • Speaker: Andy Zhu Modeling and Simulation, Department of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., Cambridge MA USA.
  • Chairs: Ryosei Kawai Clinical Science Japan, Bayer Yakuhin, Ltd.
  •  Takayo Ueno Clinical Pharmacology Strategy, Bristol-Myers Squibb K.K.
  • "Using mechanistic physiological models to enhance oncology research and drug development"
  • Speaker: Michael Reed Rosa & Co., LLC, USA

Symposium 5

November 29 (Wed.) 15:00-17:00 Room B (5F Small Hall)

Imaging Technologies: Emerging Modality for Drug Development and PD/Tox Marker Discovery

  • Organizer: Akio Kawamura Pharmacokinetics & Toxicology Laboratories, Senju Pharmaceutical Co., Ltd.
  • Organizer / Chair: Nobuaki Watanabe Drug Metabolism & Pharmacokinetics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd.
  • Chair: Hidefumi Kaji Advanced Medical Business Development Department, Drug Development Service Segment, LSI Medience Corporation
  • "Introduction of our symposium"
  • Speaker: Akio Kawamura Pharmacokinetics & Toxicology Laboratories, Senju Pharmaceutical Co., Ltd.
  • "PET Imaging in Drug Development"
  • Speaker: Akihiro Noda Bioimaging, Analysis & Pharmacokinetics Research Labs., Drug Discovery Research, Astellas Pharma Inc.
  • "Optical imaging in vivo: IVIS & MSOT"
  • Speaker: Rira Watanabe Biomarker Department, R&D Division, Daiichi Sankyo Co., Ltd.
  • "Potentialities of application of MALDI mass spectrometry imaging to pharmacokinetics studies"
  • Speaker: Masanobu Nishidate Clinical Bioanalytics Group Translational Clinical Research Science & Strategy Dept., Chugai Pharmaceutical Co., Ltd.
  • "Distribution Analysis of Epertinib in Brain Metastasis of HER2-positive Breast Cancer by Imaging Mass Spectrometry and Prospect for Antitumor Activity"
  • Speaker: Yukari Tanaka Drug Metabolism and Pharmacokinetics, Research Laboratory for Development, SHIONOGI & CO., LTD.

Symposium 6

November 29 (Wed.) 15:00-17:25 Room C (2F Tougen-Fukuju)

How we can apply the metabolomics data to find biomarkers for the drug effect?

  • Organizer / Chair: Hiroyuki Kusuhara Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • Chair: Tappei Takada Department of Pharmacy, the University of Tokyo Hospital
  • "Contribution of DMPK Researchers to Biomarker Research in Drug Development"
  • Speaker: Noriko Okudaira Clinical Pharmacology Department, R&D Division, Daiichi Sankyo Co., Ltd.
  • "Advanced lipidomics to identify the functional metabolites of omega-3 polyunsaturated fatty acids"
  • Speaker: Makoto Arita Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy / RIKEN-IMS
  • "Chrono-omics analysis for exploring diagnostic and therapeutic targets of neuropathic pain"
  • Speaker: Satoru Koyanagi Faculty of Pharmaceutical Sciences, Kyushu University
  • "Biomarker Research for Drug-Induced Liver Injury in Rats"
  • Speaker: Makoto Yamazaki DMPK Research Laboratories, Mitsubishi Tanabe Pharma Corporation
  • "Utilization of a large-scale metabolome reference for analysis of drug metabolism"
  • Speaker: Daisuke Saigusa Tohoku Medical Megabank Organization / School of Medicine, Tohoku University
  • "Screening of Endogenous Substrates of SLC22A4 by Metabolomic Approach Based on Transporting Activity and Substrate Recognition"
  • Speaker: Yusuke Masuo Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • "Early Risk Assessment for hepatic OATP-mediated Drug Interactions by Evaluation of Endogenous Substrates"
  • Speaker: Issey Takehara Biomarker Department, R&D Division, Daiichi Sankyo Co., Ltd.

Symposium 7

November 30 (Thu.) 9:30-11:30 Room A (5F Big Hall)

Expansion of the field of transporter research ~Transporter meets new fields~

  • Organizer: Ikumi Tamai Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
  • Chairs: Masahiro Okuda Department of Pharmacy, Mie University Hospital
  •  Kazuya Maeda Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • "Lysosome-resident amino acid/oligopeptide transporter, SLC15A4, as a therapeutic target for systemic lupus erythematosus"
  • Speaker: Noriko Sorimachi Department of Molecular Immunology and Inflammation, Research Institute National Center for Global Health and Medicine
  • "Impact of interplay between facilitated diffusion and metabolism on intracellular accumulation of purine nucleobases and their analogues"
  • Speaker: Katsuhisa Inoue Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • "Transporter meets hepatitis viruses"
  • Speaker: Koichi Watashi Department of Virology II, National Institute of Infectious Diseases
  • "Synthetic Molecules for Detecting and Eliminating Human Pluripotent Stem Cells"
  • Speaker: Motonari Uesugi Institute for Chemical Research, Kyoto University

Symposium 8

November 30 (Thu.) 9:30-11:30 Room C (2F Tougen-Fukuju)

Investigations of physiological function of metabolizing enzymes and applications to drug discovery

  • Organizer: Miki Nakajima Faculty of Pharmaceutical Sciences, Kanazawa University
  • Chairs: Seigo Sanoh Graduate School of Biomedical and Health Sciences, Hiroshima University
  •  Tetsuya Nakagawa Preclinical Research Laboratories, Sumitomo Dainippon Pharma Co., Ltd.
  • "Inflammation- and disease-associated regulation of drug-metabolizing enzymes in the liver"
  • Speaker: Kouichi Yoshinari Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka
  • "Physiological functions of xenobiotic-metabolizing CYP3A enzymes"
  • Speaker: Kaoru Kobayashi Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University
  • "Cytochrome P450 involved in biotransformation of both endogenous and xenobiotic substances"
  • Speaker: Takanori Hashizume Laboratory of Drug Metabolism & Pharmacokinetics, Faculty of Pharmacy, Osaka Ohtani University
  • "Metabolism and physiological function of exogenous and endogenous substances by drug-oxidizing enzymes"
  • Speaker: Hiroshi Yamazaki Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
  • "Pathophysiological function of human CYP2J2 in cancer and its inhibitors influencing potential antitumor effects"
  • Speaker: Satoshi Yamaori Department of Pharmacy, Shinshu University Hospital

Symposium 9

December 1(Fri.)9:30-12:00 Room A (5F Big Hall)

New drug treatments and the precision medicine for cancer therapy

  • Organizer: Ichiro Ieiri Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University
  • Chairs: Satohiro Masuda Department of Pharmacy, Kyushu University Hospital
  •  Hitoshi Ishizuka Daiichi Sankyo Co., Ltd.
  • "Lung cancer therapy targeted against driver gene alterations: Clinical evidence and translational research"
  • Speaker: Tetsuya Mitsudomi Thoracic Surgery, Faculty of Medicine, Kindai University
  • "Modelling of population pharmacokinetics (PK) and pharmacodynamics (PD) of antibody-drug conjugates (ADC): a case study of DS-8201a, a novel HER2-targeting ADC"
  • Speaker: Kazutaka Yoshihara Clinical Pharmacology Department, R&D Division, Daiichi Sankyo Co., Ltd.
  • "Clinical advantages of a nanoparticle albumin-bound paclitaxel (ABRAXANE®)"
  • Speaker: Ikuo Yamamiya Pharmacokinetics Research Laboratories, TAIHO Pharmaceutical Co. Ltd.
  • "Molecular targeting anti-tumor drug development of ALK inhibitor, alectinib; Key features contributed the precision medicine for cancer therapy"
  • Speaker: Hisakazu Katsuki Translational Clinical Research Science & Strategy Dept., Chugai Pharmaceutical Co., Ltd.
  • Title : unfixed
  • Speaker: Shigehisa Kitano National Cancer Center Hospital

Symposium 10

December 1(Fri.)9:30-12:00 Room B (5F Small Hall)

New horizon of microphysiological system (in vitro) technology oriented to prediction of human pharmacokinetic "Prediction of biliary excretion clearance"

  • Organizer / Chair: Shuichi Sekine Laboratory of Biopharmaceutics, Graduate school of Pharmaceutical Sciences, Chiba University
  • Chair: Kenji Tabata Analysis & Pharmacokinetics Research Labs., Institute for Drug Discovery Research, Astellas Pharma. Inc.
  • "Expectations for microphysiological systems of the liver in the assessment of drug metabolism, transport, and toxicity in drug discovery"
  • Speaker: Kazuhiro Tetsuka Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc.
  • "Two-dimensional Culture System of Human Hepatocytes for in vitro ADMET Studies using Hepatocytes Isolated from Chimeric Mice with Humanized Livers"
  • Speaker: Chise Tateno-Mukaidani Research and Development Department, PhoenixBio Co., Ltd.
  • "An approach to the construction of three-dimensional hepatic tissues using a microfluidic device"
  • Speaker: Ryo Sudo Department of System Design Engineering, Faculty of Science and Technology, Keio University
  • "Construction of In Vitro MPS Technology Based on 3D-Blood Capillary Models"
  • Speaker: Michiya Matsusaki Department of Applied Chemistry, Graduate School of Engineering, Osaka University
  • "Generation of functional hepatocytes from human pluripotent stem cells for pharmaceutical research"
  • Speaker: Hiroyuki Mizuguchi Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University

Symposium 11

December 1(Fri.)9:30-12:00 Room D(2F Heian)

Development of oligonucleotide pharmaceuticals promoted by pharmacokinetics

  • Organizer / Chair: Takashi Kuwabara Department of Clinical Pharmacy, Yokohama University of Pharmacy
  • Chair: Hiroshi Kodaira Kyowa Hakko Kirin Co., Ltd., R&D Division, Research Functions Unit, Research Core Function Laboratories
  • "Current status of research & development of Nucleic acid Therapeutics"
  • Speaker: Makoto Koizumi Modality Research Laboratories, Biologics Division, Daiichi Sankyo Co., Ltd.
  • "New Paradime of treatment for Spinal Muscular Atrophy with Antisense oligonucleotide therapy, Nusinersen - its mode of action and clinical applications -"
  • Speaker: Shinichi Torii Biogen Japan Ltd.
  • "Development of antisense drug targeting PCSK9"
  • Speaker: Mariko Harada-Shiba Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute
  • "Muscular delivery of siRNA by Conjugation of Anti-CD71 Fab' Fragment"
  • Speaker: Kenichi Miyata Innovative Biology Laboratories, Takeda Pharmaceutical Company Limited
  • "Exosomes: Naturally occurring vesicles for nucleic acid delivery"
  • Speaker: Yusuke Yoshioka Division of Molecular and Cellular Medicine, National Cancer Center Research Institute

Symposium 12

December 1(Fri.)14:00-16:30 Room A (5F Big Hall)

Recent regulatory topics for DMPK researchers

  • Organizer: Yoshiro Saito Division of Medicinal Safety Science, National Institute of Health Sciences
  • Chairs: Shinichi Ninomiya Drug Development Solutions Division, Pharma & Research Business, Sekisui Medical Co., LTD.
  •  Nobuaki Watanabe Drug Metabolism & Pharmacokinetics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd.
  • "Guideline on population pharmacokinetic and pharmacodynamic and recent trends population pharmacokinetic and pharmacodynamic analysis in regulatory review"
  • Speaker: Yoshinori Ochiai Advanced Review with Electronic Data Promotion Group/Office of New Drug I, Pharmaceuticals and Medical Devices Agency
  • "Revision of ICH S5 Guideline"
  • Speaker: Kazushige Maki Office of New Drug III, Pharmaceuticals and Medical Devices Agency
  • Drafting the "Questions and Answers" for the ICH S9 guideline, "Nonclinical Evaluation for Anticancer Pharmaceuticals"
  • Speaker: Dai Nakae Laboratory of Food Safety Assessment Science, Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture
  • "ICH S11 Nonclinical Safety Testing in Support of Development of Pediatric Medicines"
  • Speaker: Yuhji Taquahashi Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences
  • "ICH M9: Biopharmaceutics Classification System-based Biowaivers"
  • Speaker: Ryosuke Kuribayashi Office of Generic drugs, Pharmaceuticals and Medical Devices Agency
  • "ICH M10: Guideline on Bioanalytical Method Validation"
  • Speaker: Akiko Ishii-Watabe Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
  • "Accelerating regulatory science initiative"
  • Speaker: Yoshiro Saito Division of Medicinal Safety Science, National Institute of Health Sciences

Symposium 13

December 1(Fri.)14:00-16:30 Room B (5F Small Hall)

How to elucidate the metabolism of new chemical entities

  • Organizer: Miki Nakajima Faculty of Pharmaceutical Sciences, Kanazawa University
  • Chairs: Kaoru Kobayashi Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University
  •  Shin-ichi Inoue Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd.
  • "Human Intestinal Raf Kinase Inhibitor Protein (RKIP) Catalyzes Prasugrel as a Bioactivation Hydrolase"
  • Speaker: Miho Kazui Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd.
  • "Aldehyde oxidase mediated drug metabolism and basic approaches in drug discovery"
  • Speaker: Tomoyuki Isobe Tokyo New Drug Research Laboratories, Kowa Co., Ltd.
  • "Identification of sulfotransferase and methyltransferase isozymes responsible for the metabolism of peficitinib, a Janus kinase inhibitor"
  • Speaker: Kazuo Oda Analysis & Pharmacokinetics Research Laboratories, Drug Discovery Research, Astellas Pharma Inc.
  • "Dipeptidyl peptidase-4 greatly contributes to the cyano group hydrolysis of vildagliptin in human liver"
  • Speaker: Mitsutoshi Asakura Department of Pharmacy, Shinshu University Hospital
  • "Roles of hydrolases and aldehyde oxidase in controlling of pharmacokinetics and drug toxicity"
  • Speaker: Tatsuki Fukami Faculty of Pharmaceutical Sciences, Kanazawa University

Symposium 14

December 1(Fri.)14:00-16:30 Room C (2F Tougen-Fukuju)

Invitation to Pharmacometrics

  • Organizer: Akihiro Hisaka Laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University
  • Chair: Takahiko Tanigawa Clinical Sciences Japan, Bayer Yakuhin, Ltd.
  • "Start Pharmacometrics from Pharmacokinetics"
  • Speaker: Koji Chiba Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy
  • Chair: Koji Chiba Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy
  • "Pharmacometrics for clinical development of New drug –Rivaroxaban as an example–"
  • Speaker: Takahiko Tanigawa Clinical Sciences Japan, Bayer Yakuhin, Ltd.
  • Chair: Hiroyuki Yoshitsugu Clinical Research Area, Japan Development, MSDK.K.
  • "MID3 (Model-Informed Drug Discovery and Development)"
  • Speaker: Akiyuki Suzuki Pharmacometrics Group, Clinical pharmacology, Pfizer Japan Inc.
  • Chair: Fumiyoshi Yamashita Graduate School of Pharmaceutical Sciences, Kyoto University
  • "Clinical research that is feasible for scientists in academia: model-based meta-analysis (MBMA)"
  • Speaker: Akihiro Hisaka Laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University
Round table discussion
  • "Science and communication skills necessary for pharmacometrics research"
  • Modulators: Atsunori Kaibara
    Clinical Pharmacology, Astellas Pharma Inc.
  • Modulators: So Miyoshi
    Clinical pharmacology, Pfizer Japan Inc.

JSSX-KSAP Joint Symposium

November 30 (Thu.) 9:30-11:30 Room B (5F Small Hall)

Drug-induced organ toxicity -Mechanism, Prediction, and Prevention-

  • Organizer / Chair from JSSX: Kousei Ito
    Graduate School of Pharmaceutical Sciences, Chiba University
  • Organizer / Chair from KSAP: Young-Jin Chun
    College of Pharmacy and Center for Metareceptome Research, Chung-Ang University, Korea
  • "Keratinocytes can predict risk for developing drug-induced liver toxicity in individuals"
  • Speaker: Ryoichi Fujiwara School of Pharmacy, Kitasato University
  • "Determination of sleep deprivation-induced brain toxicity by multi-platform mass spectrometry"
  • Speaker: Sung Won Kwon College of Pharmacy, Seoul National University, Korea
  • "Reconstitution of drug hypersensitivity reaction in HLA-transgenic mice model"
  • Speaker: Kousei Ito Graduate School of Pharmaceutical Sciences, Chiba University
  • "Roles of Annexin A5 in Mitochondria-Dependent Apoptosis Induced by Various Anticancer Drugs"
  • Speaker: Young-Jin Chun College of Pharmacy and Center for Metareceptome Research, Chung-Ang University, Korea

Basic Course

December 1(Fri.)9:30-12:00 Room C (2F Tougen-Fukuju)

Basic course of pharmacokinetics related to drug development

  • Organizers / Chairs: Hiroyuki Kusuhara Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
  •  Motohiro Kato Drug Metabolism and Pharmacokinetics Research Labs., Chugai Pharmaceutical Co., LTD.
  • "Basic Pharmacokinetics, which you can not ask about even now.
    -Illustrated study guide for effectively utilizing Pharmacokinetics-"
  • Lecturers: Hideki Hirabayashi Takeda Pharmaceutical Company Limited
  • "Basics of PK/PD analysis -Model selection and parameter estimation-"
  • Lecturers: Tatsuhiko Tachibana Pre-clinical Research Department, Chugai Pharmaceutical Co., LTD.

3rd Predoctoral Symposium for Front-Line Scientists

November 30 (Thu.) 15:00-17:30 Room E(2F Zuiun)

Pharmacokinetic research for leading the future medicine

  • Organizers: Daichi Onozato Graduate School of Pharmaceutical Sciences, Nagoya City University
  •  Ayako Tokunaga Graduate School of Biomedical Sciences, Nagasaki University
  •  Kaori Miyazaki Graduate School of Pharmaceutical Sciences, Tokyo University of Pharmacy and Life Sciences
  • Chair: Yoshihisa Mimura Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University
  • "A New Mechanism of Drug-Beverage Interaction: Effect of Solution Osmolality on Luminal Water Volume and Drug Absorption in Intestine"
  • Speaker: Kazuki Ichijo Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • Chair: Masaki Takahashi Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • "Development of a novel differentiation method of human induced pluripotent stem cell-derived enterocytes"
  • Speaker: Tomoki Kabeya Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
  • Chair: Hiromasa Aoki Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
  • "Distribution of doxorubicin in the embryo after administration to the mother"
  • Speaker: Satoshi Kitaoka Department of Clinical pharmacokinetics, Graduate School of Pharmaceutical Sciences, Hoshi University
  • Chair: Yu Takahashi Division of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Keio University
  • "Design and evaluation of long-acting thioredoxin by using albumin fusion technology as a therapeutic agent for acute kidney injury and its crosstalk with other organs"
  • Speaker: Kento Nishida Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University
  • Chair: Hiroki Kamioka Laboratory of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Takasaki University of Health and Welfare
  • "Substrate specificities of UDP-glucuronosyltransferase in rats and mice: comparison with human UGT isoforms"
  • Speaker: Hiroki Oki Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University
  • Chair: Daichi Onozato Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
  • "Development of a novel alveolar epithelial cell model and its application to the study on drug-induced epithelial-mesenchymal transition"
  • Speaker: Junya Deguchi Department of Pharmaceutics and Therapeutics, Graduate school of Biomedical & Health Sciences, Hiroshima University
Education Lecture
  • Chairs: Ayako Tokunaga Department of Pharmaceutics, Graduate School of Biomedical Sciences, Nagasaki University
  •  Kaori Miyazaki Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • "Studies on drug fostering, pharmaceutical technology, drug discovery based on biological clock"
  • Speaker: Naoya Matsunaga Department of Glocal Healthcare, Graduate School of Pharmaceutical Science, Kyushu University

General Session

Oral Presentation

Poster Presentation (Final for Best Poster Award)

Poster Presentation