Program

Timetable

Distinguished Lecture 1

November 29 (Wed.) 13:50-14:50 Room A (5F Big Hall)

Variability of drug metabolism due to (epi)genetic and (patho)physiological factors - the struggle for better prediction

Chairs: Hiroshi Yamazaki Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
Miki Nakajima Faculty of Pharmaceutical Sciences, Kanazawa University
Speaker: Ulrich M. Zanger Molecular and Cell Biology, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Germany

Distinguished Lecture 2

November 30 (Thu.) 13:00-14:00 Room A (5F Big Hall)

Establishing the Selectivity of Organic Cation Transporters: Grappling with Inconvenient Truths

Chair: Mikihisa Takano Graduate School of Biomedical & Health Sciences, Hiroshima University
Carsten Ehrhardt School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin
Speaker: Stephen H. Wright Department of Physiology, College of Medicine, University of Arizona, Tucson, AZ

President's Lecture

November 30 (Thu.) 15:30-16:00 Room A (5F Big Hall)

Message from the JSSX President: Current topics in drug metabolism and pharmacokinetics and clinical pharmacotherapy

Chair: Mikihisa Takano Graduate School of Biomedical & Health Sciences, Hiroshima University
Speaker: Hiroshi Yamazaki Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University

Symposium 1

November 29 (Wed.) 9:30-11:30 Room A (5F Big Hall)

Recent topics of interface of between "Drug Metabolism and Pharmacokinetics" and "Toxicology"

Organizer: Miki Nakajima Faculty of Pharmaceutical Sciences, Kanazawa University
Chairs: Kousei Ito Graduate School of Pharmaceutical Sciences, Chiba University
Yoichi Naritomi Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc.

"Strategic Drug Design to Eliminate Metabolic Activation of Hapatotoxic Drugs"
Speaker: Tomoyuki Ohe Faculty of Pharmacy, Keio University
"Application of cytochrome P450 reactivity assessment to liver toxicity prediction"
Speaker: Takamitsu Sasaki Depertment of Molecular Toxicology, School of Phrmaceutical Sciences, University of Shizuoka
"Bile acid dependent hepatocytes toxicity - beyond BSEP inhibition by parent drug"
Speakers: Kousei Ito Graduate School of Pharmaceutical Sciences, Chiba University
"Assessment of drug-induced hepatotoxicity, considering drug metabolism, using 3-D hepatocyte cultures and chimeric mice with humanized liver"
Speaker: Seigo Sanoh Graduate School of Biomedical and Health Sciences, Hiroshima University

Symposium 2

November 29 (Wed.) 9:30-11:30 Room B (5F Small Hall)

Roles of Pharmacokinetic Studies on Cell Therapeutics

Organizer: Takashi Kuwabara Department of Clinical Pharmacy, Yokohama University of Pharmacy
Chairs: Makiya Nishikawa Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science
Masataka Oitate Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd.

"Biodistribution evaluation in "MEASURE", the Multisite Evaluation Study on Analytical Methods for Non-clinical Safety Assessment of Human-derived Regenerative Medical Products"
Speaker: Masahiro Yahata Preclinical Research Laboratories, Sumitomo Dainippon Pharma Co., Ltd.
"Biodistribution study of human mesenchymal stem cells in mice using ARLG, IVIS, and qPCR"
Speaker: Takahiro Nakamura Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd.
"Cell-based therapy with high safety through manipulating the in vivo fate of transplanted cells"
Speaker: Kosuke Kusamori Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science
"Cell-injection therapy for the treatment of corneal endothelial dysfunction"
Speaker: Noriko Koizumi Department of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University

Symposium 3

November 29 (Wed.) 9:30-11:30 Room C (2F Tougen-Fukuju)

From academic research to clinic based on cooperation between industry, government and academia

Organizers / Chairs: Hideyoshi Harashima Faculty of Pharmaceutical Sciences Laboratory for Molecular Design of Pharmaceutics, Hokkaido University
Yoshinobu Takakura Graduate School and Faculty of Pharmaceutical Sciences, Kyoto University

"Drug discovery Innovation for nonstandard peptides"
Speaker: Hiroaki Suga Department of Chemistry, Graduate School of Science, The University of Tokyo
"Model-based Population Pharmacokinetic Analysis and Exposure-Response Analysis of Nivolumab"
Speaker: Tomoya Ohno ONO Pharmaceutical CO., LTD., Translational Medicine Center, Clinical Pharmacology
"Viewpoint on Assessment of Healthcare Technologies"
Speaker: Yoshihide Esaki Ministry of Economy, Trade and Industry
"Challenge to improve probability of drug discovery and streamline clinical development cost"
Speaker: Kazuhiko Mori Ministry of Health, Labour and Welfare

Symposium 4

November 29 (Wed.) 15:00-17:00 Room A (5F Big Hall)

QSP in oncology - practical application, challenge and opportunity -

Organizers: Masayo Oishi Clinical pharmacology, Pfizer Japan Inc.
Koji Chiba Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy.

Chairs: Hiroto Hatakeyama Laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University
Naomi Nagai Department of Pharmaceutical Sciences, Musashino University
"Systems-based understanding of mechanisms underlying the adverse reactions with kinase inhibitors"
Speaker: Masashi Honma Department of Pharmacy, the University of Tokyo Hospital

Chairs: Yuko Mori Clinical pharmacology, Pfizer Japan Inc.
Yasuhisa Nagasaka Quantitative Systems Pharmacology, Analysis & Pharmacokinetics Research Labs, Astellas Pharma Inc.
"QSP Models in Preclinical Oncology Drug Discovery"
Speaker: Mary E. Spilker Translational Modeling and Simulation, Medicine Design, Pfizer Worldwide Research and Development

Chairs: Teruki Hamada Drug Disposition & Analysis, Research Division, Axcelead Drug Discovery Partners, Inc.
Noriko Okudaira Clinical Pharmacology Department, R&D Division, Daiichi Sankyo Co., Ltd.
"An Integrated Mechanistic Model to Characterize Efficacy and Toxicity of Antibody Drug Conjugates"
Speaker: Andy Zhu Modeling and Simulation, Department of Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals International Co., Cambridge MA USA.

Chairs: Ryosei Kawai Clinical Science Japan, Bayer Yakuhin, Ltd.
Takayo Ueno Clinical Pharmacology Strategy, Bristol-Myers Squibb K.K.
"Using mechanistic physiological models to enhance oncology research and drug development"
Speaker: Michael Reed Rosa & Co., LLC, USA

Symposium 5

November 29 (Wed.) 15:00-17:00 Room B (5F Small Hall)

Imaging Technologies: Emerging Modality for Drug Development and PD/Tox Marker Discovery

Organizer: Akio Kawamura Pharmacokinetics & Toxicology Laboratories, Senju Pharmaceutical Co., Ltd.
Organizer / Chair: Nobuaki Watanabe Drug Metabolism & Pharmacokinetics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd.
Chair: Hidefumi Kaji Advanced Medical Business Development Department, Drug Development Service Segment, LSI Medience Corporation

"Introduction of our symposium"
Speaker: Akio Kawamura Pharmacokinetics & Toxicology Laboratories, Senju Pharmaceutical Co., Ltd.
"PET Imaging in Drug Development"
Speaker: Akihiro Noda Bioimaging, Analysis & Pharmacokinetics Research Labs., Drug Discovery Research, Astellas Pharma Inc.
"Optical imaging in vivo: IVIS & MSOT"
Speaker: Rira Watanabe Biomarker Department, R&D Division, Daiichi Sankyo Co., Ltd.
"Potentialities of application of MALDI mass spectrometry imaging to pharmacokinetics studies"
Speaker: Masanobu Nishidate Clinical Bioanalytics Group Translational Clinical Research Science & Strategy Dept., Chugai Pharmaceutical Co., Ltd.
"Distribution Analysis of Epertinib in Brain Metastasis of HER2-positive Breast Cancer by Imaging Mass Spectrometry and Prospect for Antitumor Activity"
Speaker: Yukari Tanaka Drug Metabolism and Pharmacokinetics, Research Laboratory for Development, SHIONOGI & CO., LTD.

Symposium 6

November 29 (Wed.) 15:00-17:25 Room C (2F Tougen-Fukuju)

How we can apply the metabolomics data to find biomarkers for the drug effect?

Organizer / Chair: Hiroyuki Kusuhara Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Chair: Tappei Takada Department of Pharmacy, the University of Tokyo Hospital

"Contribution of DMPK Researchers to Biomarker Research in Drug Development"
Speaker: Noriko Okudaira Clinical Pharmacology Department, R&D Division, Daiichi Sankyo Co., Ltd.
"Advanced lipidomics to identify the functional metabolites of omega-3 polyunsaturated fatty acids"
Speaker: Makoto Arita Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy / RIKEN-IMS
"Chrono-omics analysis for exploring diagnostic and therapeutic targets of neuropathic pain"
Speaker: Satoru Koyanagi Faculty of Pharmaceutical Sciences, Kyushu University
"Biomarker Research for Drug-Induced Liver Injury in Rats"
Speaker: Makoto Yamazaki DMPK Research Laboratories, Mitsubishi Tanabe Pharma Corporation
"Utilization of a large-scale metabolome reference for analysis of drug metabolism"
Speaker: Daisuke Saigusa Tohoku Medical Megabank Organization / School of Medicine, Tohoku University
"Screening of Endogenous Substrates of SLC22A4 by Metabolomic Approach Based on Transporting Activity and Substrate Recognition"
Speaker: Yusuke Masuo Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
"Early Risk Assessment for hepatic OATP-mediated Drug Interactions by Evaluation of Endogenous Substrates"
Speaker: Issey Takehara Biomarker Department, R&D Division, Daiichi Sankyo Co., Ltd.

Symposium 7

November 30 (Thu.) 9:30-11:30 Room A (5F Big Hall)

Expansion of the field of transporter research ~Transporter meets new fields~

Organizer: Ikumi Tamai Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
Chairs: Masahiro Okuda Department of Pharmacy, Mie University Hospital
Kazuya Maeda Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo

"Lysosome-resident amino acid/oligopeptide transporter, SLC15A4, as a therapeutic target for systemic lupus erythematosus"
Speaker: Noriko Sorimachi Department of Molecular Immunology and Inflammation, Research Institute National Center for Global Health and Medicine
"Impact of interplay between facilitated diffusion and metabolism on intracellular accumulation of purine nucleobases and their analogues"
Speaker: Katsuhisa Inoue Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
"Transporter meets hepatitis viruses"
Speaker: Koichi Watashi Department of Virology II, National Institute of Infectious Diseases
"Synthetic Molecules for Detecting and Eliminating Human Pluripotent Stem Cells"
Speaker: Motonari Uesugi Institute for Chemical Research, Kyoto University

Symposium 8

November 30 (Thu.) 9:30-11:30 Room C (2F Tougen-Fukuju)

Investigations of physiological function of metabolizing enzymes and applications to drug discovery

Organizer: Miki Nakajima Faculty of Pharmaceutical Sciences, Kanazawa University
Chairs: Seigo Sanoh Graduate School of Biomedical and Health Sciences, Hiroshima University
Tetsuya Nakagawa Preclinical Research Laboratories, Sumitomo Dainippon Pharma Co., Ltd.

"Inflammation- and disease-associated regulation of drug-metabolizing enzymes in the liver"
Speaker: Kouichi Yoshinari Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka
"Physiological functions of xenobiotic-metabolizing CYP3A enzymes"
Speaker: Kaoru Kobayashi Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University
"Cytochrome P450 involved in biotransformation of both endogenous and xenobiotic substances"
Speaker: Takanori Hashizume Laboratory of Drug Metabolism & Pharmacokinetics, Faculty of Pharmacy, Osaka Ohtani University
"Metabolism and physiological function of exogenous and endogenous substances by drug-oxidizing enzymes"
Speaker: Hiroshi Yamazaki Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
"Pathophysiological function of human CYP2J2 in cancer and its inhibitors influencing potential antitumor effects"
Speaker: Satoshi Yamaori Department of Pharmacy, Shinshu University Hospital

Symposium 9

December 1(Fri.)9:30-12:00 Room A (5F Big Hall)

New drug treatments and the precision medicine for cancer therapy

Organizer: Ichiro Ieiri Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University
Chairs: Satohiro Masuda Department of Pharmacy, Kyushu University Hospital
Hitoshi Ishizuka Daiichi Sankyo Co., Ltd.

"Lung cancer therapy targeted against driver gene alterations: Clinical evidence and translational research"
Speaker: Tetsuya Mitsudomi Thoracic Surgery, Faculty of Medicine, Kindai University
"Modelling of population pharmacokinetics (PK) and pharmacodynamics (PD) of antibody-drug conjugates (ADC): a case study of DS-8201a, a novel HER2-targeting ADC"
Speaker: Kazutaka Yoshihara Clinical Pharmacology Department, R&D Division, Daiichi Sankyo Co., Ltd.
"Clinical advantages of a nanoparticle albumin-bound paclitaxel (ABRAXANE®)"
Speaker: Ikuo Yamamiya Pharmacokinetics Research Laboratories, TAIHO Pharmaceutical Co. Ltd.
"Molecular targeting anti-tumor drug development of ALK inhibitor, alectinib; Key features contributed the precision medicine for cancer therapy"
Speaker: Hisakazu Katsuki Translational Clinical Research Science & Strategy Dept., Chugai Pharmaceutical Co., Ltd.
Title : unfixed
Speaker: Shigehisa Kitano National Cancer Center Hospital

Symposium 10

December 1(Fri.)9:30-12:00 Room B (5F Small Hall)

New horizon of microphysiological system (in vitro) technology oriented to prediction of human pharmacokinetic "Prediction of biliary excretion clearance"

Organizer / Chair: Shuichi Sekine Laboratory of Biopharmaceutics, Graduate school of Pharmaceutical Sciences, Chiba University
Chair: Kenji Tabata Analysis & Pharmacokinetics Research Labs., Institute for Drug Discovery Research, Astellas Pharma. Inc.

"Expectations for microphysiological systems of the liver in the assessment of drug metabolism, transport, and toxicity in drug discovery"
Speaker: Kazuhiro Tetsuka Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc.
"Two-dimensional Culture System of Human Hepatocytes for in vitro ADMET Studies using Hepatocytes Isolated from Chimeric Mice with Humanized Livers"
Speaker: Chise Tateno-Mukaidani Research and Development Department, PhoenixBio Co., Ltd.
"An approach to the construction of three-dimensional hepatic tissues using a microfluidic device"
Speaker: Ryo Sudo Department of System Design Engineering, Faculty of Science and Technology, Keio University
"Construction of In Vitro MPS Technology Based on 3D-Blood Capillary Models"
Speaker: Michiya Matsusaki Department of Applied Chemistry, Graduate School of Engineering, Osaka University
"Generation of functional hepatocytes from human pluripotent stem cells for pharmaceutical research"
Speaker: Hiroyuki Mizuguchi Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University

Symposium 11

December 1(Fri.)9:30-12:00 Room D(2F Heian)

Development of oligonucleotide pharmaceuticals promoted by pharmacokinetics

Organizer / Chair: Takashi Kuwabara Department of Clinical Pharmacy, Yokohama University of Pharmacy
Chair: Hiroshi Kodaira Kyowa Hakko Kirin Co., Ltd., R&D Division, Research Functions Unit, Research Core Function Laboratories

"Current status of research & development of Nucleic acid Therapeutics"
Speaker: Makoto Koizumi Modality Research Laboratories, Biologics Division, Daiichi Sankyo Co., Ltd.
"New Paradime of treatment for Spinal Muscular Atrophy with Antisense oligonucleotide therapy, Nusinersen - its mode of action and clinical applications -"
Speaker: Shinichi Torii Biogen Japan Ltd.
"Development of antisense drug targeting PCSK9"
Speaker: Mariko Harada-Shiba Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute
"Muscular delivery of siRNA by Conjugation of Anti-CD71 Fab' Fragment"
Speaker: Kenichi Miyata Innovative Biology Laboratories, Takeda Pharmaceutical Company Limited
"Exosomes: Naturally occurring vesicles for nucleic acid delivery"
Speaker: Yusuke Yoshioka Division of Molecular and Cellular Medicine, National Cancer Center Research Institute

Symposium 12

December 1(Fri.)14:00-16:30 Room A (5F Big Hall)

Recent regulatory topics for DMPK researchers

Organizer: Yoshiro Saito Division of Medicinal Safety Science, National Institute of Health Sciences
Chairs: Shinichi Ninomiya Drug Development Solutions Division, Pharma & Research Business, Sekisui Medical Co., LTD.
Nobuaki Watanabe Drug Metabolism & Pharmacokinetics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd.

"Guideline on population pharmacokinetic and pharmacodynamic and recent trends population pharmacokinetic and pharmacodynamic analysis in regulatory review"
Speaker: Yoshinori Ochiai Advanced Review with Electronic Data Promotion Group/Office of New Drug I, Pharmaceuticals and Medical Devices Agency
"Revision of ICH S5 Guideline"
Speaker: Kazushige Maki Office of New Drug III, Pharmaceuticals and Medical Devices Agency
Drafting the "Questions and Answers" for the ICH S9 guideline, "Nonclinical Evaluation for Anticancer Pharmaceuticals"
Speaker: Dai Nakae Laboratory of Food Safety Assessment Science, Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture
"ICH S11 Nonclinical Safety Testing in Support of Development of Pediatric Medicines"
Speaker: Yuhji Taquahashi Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences
"ICH M9: Biopharmaceutics Classification System-based Biowaivers"
Speaker: Ryosuke Kuribayashi Office of Generic drugs, Pharmaceuticals and Medical Devices Agency
"ICH M10: Guideline on Bioanalytical Method Validation"
Speaker: Akiko Ishii-Watabe Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
"Accelerating regulatory science initiative"
Speaker: Yoshiro Saito Division of Medicinal Safety Science, National Institute of Health Sciences

Symposium 13

December 1(Fri.)14:00-16:30 Room B (5F Small Hall)

How to elucidate the metabolism of new chemical entities

Organizer: Miki Nakajima Faculty of Pharmaceutical Sciences, Kanazawa University
Chairs: Kaoru Kobayashi Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University
Shin-ichi Inoue Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd.

"Human Intestinal Raf Kinase Inhibitor Protein (RKIP) Catalyzes Prasugrel as a Bioactivation Hydrolase"
Speaker: Miho Kazui Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd.
"Aldehyde oxidase mediated drug metabolism and basic approaches in drug discovery"
Speaker: Tomoyuki Isobe Tokyo New Drug Research Laboratories, Kowa Co., Ltd.
"Identification of sulfotransferase and methyltransferase isozymes responsible for the metabolism of peficitinib, a Janus kinase inhibitor"
Speaker: Kazuo Oda Analysis & Pharmacokinetics Research Laboratories, Drug Discovery Research, Astellas Pharma Inc.
"Dipeptidyl peptidase-4 greatly contributes to the cyano group hydrolysis of vildagliptin in human liver"
Speaker: Mitsutoshi Asakura Department of Pharmacy, Shinshu University Hospital
"Roles of hydrolases and aldehyde oxidase in controlling of pharmacokinetics and drug toxicity"
Speaker: Tatsuki Fukami Faculty of Pharmaceutical Sciences, Kanazawa University

Symposium 14

December 1(Fri.)14:00-16:30 Room C (2F Tougen-Fukuju)

Invitation to Pharmacometrics

Organizer: Akihiro Hisaka Laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University

Chair: Takahiko Tanigawa Clinical Sciences Japan, Bayer Yakuhin, Ltd.
"Start Pharmacometrics from Pharmacokinetics"
Speaker: Koji Chiba Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy

Chair: Koji Chiba Laboratory of Clinical Pharmacology, Yokohama University of Pharmacy
"Pharmacometrics for clinical development of New drug –Rivaroxaban as an example–"
Speaker: Takahiko Tanigawa Clinical Sciences Japan, Bayer Yakuhin, Ltd.

Chair: Hiroyuki Yoshitsugu Clinical Research Area, Japan Development, MSDK.K.
"MID3 (Model-Informed Drug Discovery and Development)"
Speaker: Akiyuki Suzuki Pharmacometrics Group, Clinical pharmacology, Pfizer Japan Inc.

Chair: Fumiyoshi Yamashita Graduate School of Pharmaceutical Sciences, Kyoto University
"Clinical research that is feasible for scientists in academia: model-based meta-analysis (MBMA)"
Speaker: Akihiro Hisaka Laboratory of Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University

Round table discussion

"Science and communication skills necessary for pharmacometrics research"
Modulators: Atsunori Kaibara
Clinical Pharmacology, Astellas Pharma Inc.
Modulators: So Miyoshi
Clinical pharmacology, Pfizer Japan Inc.

JSSX-KSAP Joint Symposium

November 30 (Thu.) 9:30-11:30 Room B (5F Small Hall)

Drug-induced organ toxicity -Mechanism, Prediction, and Prevention-

Organizer / Chair from JSSX: Kousei Ito
Graduate School of Pharmaceutical Sciences, Chiba University
Organizer / Chair from KSAP: Young-Jin Chun
College of Pharmacy and Center for Metareceptome Research, Chung-Ang University, Korea

"Keratinocytes can predict risk for developing drug-induced liver toxicity in individuals"
Speaker: Ryoichi Fujiwara School of Pharmacy, Kitasato University
"Determination of sleep deprivation-induced brain toxicity by multi-platform mass spectrometry"
Speaker: Sung Won Kwon College of Pharmacy, Seoul National University, Korea
"Reconstitution of drug hypersensitivity reaction in HLA-transgenic mice model"
Speaker: Kousei Ito Graduate School of Pharmaceutical Sciences, Chiba University
"Roles of Annexin A5 in Mitochondria-Dependent Apoptosis Induced by Various Anticancer Drugs"
Speaker: Young-Jin Chun College of Pharmacy and Center for Metareceptome Research, Chung-Ang University, Korea

Basic Course

December 1(Fri.)9:30-12:00 Room C (2F Tougen-Fukuju)

Basic course of pharmacokinetics related to drug development

Organizers / Chairs: Hiroyuki Kusuhara Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Motohiro Kato Drug Metabolism and Pharmacokinetics Research Labs., Chugai Pharmaceutical Co., LTD.

"Basic Pharmacokinetics, which you can not ask about even now.
-Illustrated study guide for effectively utilizing Pharmacokinetics-"
Lecturers: Hideki Hirabayashi Takeda Pharmaceutical Company Limited
"Basics of PK/PD analysis -Model selection and parameter estimation-"
Lecturers: Tatsuhiko Tachibana Pre-clinical Research Department, Chugai Pharmaceutical Co., LTD.

3rd Predoctoral Symposium for Front-Line Scientists

November 30 (Thu.) 15:00-17:30 Room E(2F Zuiun)

Pharmacokinetic research for leading the future medicine

Organizers: Daichi Onozato Graduate School of Pharmaceutical Sciences, Nagoya City University
Ayako Tokunaga Graduate School of Biomedical Sciences, Nagasaki University
Kaori Miyazaki Graduate School of Pharmaceutical Sciences, Tokyo University of Pharmacy and Life Sciences

Chair: Yoshihisa Mimura Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Nagoya City University
"A New Mechanism of Drug-Beverage Interaction: Effect of Solution Osmolality on Luminal Water Volume and Drug Absorption in Intestine"
Speaker: Kazuki Ichijo Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Chair: Masaki Takahashi Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
"Development of a novel differentiation method of human induced pluripotent stem cell-derived enterocytes"
Speaker: Tomoki Kabeya Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University

Chair: Hiromasa Aoki Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
"Distribution of doxorubicin in the embryo after administration to the mother"
Speaker: Satoshi Kitaoka Department of Clinical pharmacokinetics, Graduate School of Pharmaceutical Sciences, Hoshi University

Chair: Yu Takahashi Division of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Keio University
"Design and evaluation of long-acting thioredoxin by using albumin fusion technology as a therapeutic agent for acute kidney injury and its crosstalk with other organs"
Speaker: Kento Nishida Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University

Chair: Hiroki Kamioka Laboratory of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Takasaki University of Health and Welfare
"Substrate specificities of UDP-glucuronosyltransferase in rats and mice: comparison with human UGT isoforms"
Speaker: Hiroki Oki Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University

Chair: Daichi Onozato Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University
"Development of a novel alveolar epithelial cell model and its application to the study on drug-induced epithelial-mesenchymal transition"
Speaker: Junya Deguchi Department of Pharmaceutics and Therapeutics, Graduate school of Biomedical & Health Sciences, Hiroshima University

Education Lecture

Chairs: Ayako Tokunaga Department of Pharmaceutics, Graduate School of Biomedical Sciences, Nagasaki University
Kaori Miyazaki Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
"Studies on drug fostering, pharmaceutical technology, drug discovery based on biological clock"
Speaker: Naoya Matsunaga Department of Glocal Healthcare, Graduate School of Pharmaceutical Science, Kyushu University

General Session

Oral Presentation

Poster Presentation (Final for Best Poster Award)

Poster Presentation